Rho GTP酶激活蛋白13抗體，Anti-SRGAP1抗體產(chǎn)品信息：
背景介紹：SRGAPs contain a highly conserved overall primary structure and play an important role in the cell facilitating Slit-robo signaling in cell migration and axon guidance. SRGAP1 (Slit-robo Rho GTPase activating protein 1), also known as ARHGAP13 (Rho GTPase activating protein 13), functions as a GTPase-activating protein for Cdc42 and Rho A. Expressed in kidney, testis, lung and brain, SRGAP1 contains an FCH (Fes/CIP4 homology) domain, a Rho-GAP domain and an SH3 domain. In the presence of Slit, SRGAP1 (via its SH3 domain) binds to the CC3 motif in robo (a protein responsible for mediating the repulsive effect of Slit) with higher affinity and inhibits Cdc42 activity in a robo/SRGAP-dependent manner. More specifically, SRGAP1 increases the intrinsic GTPase activity of Cdc42, thereby converting it to its inactive, GDP-bound form. Inactivation of Cdc42 ultimay leads to a decrease in actin polymerization.
英文名稱：Anti-SRGAP1
中文名稱：Rho GTP酶激活蛋白13抗體
產(chǎn)品規(guī)格：50ul；100ul；200ul；1ml，*
Rho GTP酶激活蛋白13抗體，Anti-SRGAP1抗體簡單介紹：
產(chǎn)品編號：BYK-10671R
別名：ARHGAP13; FLJ22166; KIAA1304; RGD1566260; Rho GTPase activating protein 13; SLIT ROBO Rho GTPase activating protein 1; SRGAP 1; SRGP1_HUMAN.
抗體來源 Rabbit or Mouse
克隆類型 Polyclonal or Monoclonal
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性 狀 Lyophilized or Liquid
濃 度 1mg/ml
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