普魯士藍(lán)號(hào)：14038-43-8   
英文名稱：Prussian Blue；Ferric ferrocyanide；Ferric hexacyanoferrate(II)；Chinese blue；Milori blue；Steel blue；Pigment blue 27；Hamburg blue；Berlin blue；Mineral blue   
其他名稱：六氰合鐵(II)酸鐵；普魯士蘭；中國藍(lán)；貢藍(lán)；鐵藍(lán)；礦藍(lán)；柏林藍(lán)；亞鐵氰化鐵；華藍(lán)；密羅里藍(lán)；深藍(lán)   
號(hào)：14038-43-8   
Fe4[Fe(CN)6]3=859.23   
級(jí)別：BS   
生物染色試驗(yàn)：合格   
性狀(以下信息僅供參考)：深藍(lán)色粉末或塊狀。250℃失去全部水分而部分分解。幾乎不溶于水、稀酸及有機(jī)溶劑。新制成品可溶于草酸溶液。通常為含有一些水份和一些堿金屬的亞鐵。相對(duì)密度 1.80。   
用途：本品僅供科研，不得用于其它用途。(以下用途僅供參考)細(xì)菌血清檢驗(yàn)中制備中國藍(lán)瓊脂培養(yǎng)基時(shí)作指示劑(配100毫升溶液用1克)。生物標(biāo)本著色。氣體中除去硫化氫。   
保存：RT 
普魯士藍(lán)號(hào)：14038-43-8儲(chǔ)存條件：
避光、干燥陰涼處封閉貯存,嚴(yán)禁與有毒、有害物品混放、混運(yùn)。本品為非危險(xiǎn) 產(chǎn)品可按一般化學(xué)品運(yùn)輸,輕搬動(dòng)輕放,防止日曬、雨淋！受熱、受潮、受光后易喪失活力,保存期短,因此貯存和運(yùn)輸條件比較苛刻。
運(yùn)輸：汽車運(yùn)輸、EMS郵政快遞，申通快遞等， 款到上海3天內(nèi)發(fā)貨；
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存儲(chǔ)：應(yīng)貯存在干燥清潔避光的環(huán)境中，嚴(yán)禁與有毒物質(zhì)混放，以免污染（保質(zhì)期為兩年）。
普魯士藍(lán)號(hào)：14038-43-8主要優(yōu)級(jí)純、分級(jí)純和化學(xué)純3種：
（1）優(yōu)級(jí)純（GR：Guaranteed reagent），又稱一級(jí)品或保證試劑，99.8%，這種試劑純度Z高，雜質(zhì)含量Z低，適合于重要精密的分析工作和科學(xué)研究工作，使用綠色瓶簽。
（2）分析純（AR），又稱二級(jí)試劑，純度很高，99.7%，略次于優(yōu)級(jí)純，適合于重要分析及一般研究工作，使用紅色瓶簽。
（3）化學(xué)純（CP），又稱三級(jí)試劑，≥ 99.5%，純度與分析純相差較大，適用于工礦、學(xué)校一般分析工作。使用藍(lán)色（深藍(lán)色）標(biāo)簽。
（4）實(shí)驗(yàn)試劑（LR：Laboratory reagent），又稱四級(jí)試劑。
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"supershift" the DNA/protein complex.
Function : NF-kappa-B is a pleiotropic transcription factor present in almost all cell types and is the endpoint of a series of signal transduction events that are initiated by a vast array of stimuli related to many biological processes such as inflammation, immunity, differentiation, cell growth, tumorigenesis and apoptosis. NF-kappa-B is a homo- or heterodimeric complex formed by the Rel-like domain-containing proteins RELA/p65, RELB, NFKB1/p105, NFKB1/p50, REL and NFKB2/p52. The dimers bind at kappa-B sites in the DNA of their target genes and the individual dimers have distinct preferences for different kappa-B sites that they can bind with distinguishable affinity and specificity. Different dimer combinations act as transcriptional activators or repressors, respectively. NF-kappa-B is controlled by various mechanisms of post-translational modification and subcellular compartmentalization as well as by interactions with other cofactors or corepressors. NF-kappa-B complexes are held in the cytoplasm in an inactive state complexed with members of the NF-kappa-B inhibitor (I-kappa-B) family. In a conventional activation pathway, I-kappa-B is phosphorylated by I-kappa-B kinases (IKKs) in response to different activators, subsequently degraded thus liberating the active NF-kappa-B complex which translocates to the nucleus. In a non-canonical activation pathway, the MAP3K14-activated CHUK/IKKA homodimer phosphorylates NFKB2/p100 associated with RelB, inducing its proteolytic processing to NFKB2/p52 and the formation of NF-kappa-B RelB-p52 complexes. The NF-kappa-B heterodimeric RelB-p52 complex is a transcriptional activator. The NF-kappa-B p52-p52 homodimer is a transcriptional repressor. NFKB2 appears to have dual functions such as cytoplasmic retention of attached NF-kappa-B proteins by p100 and generation of p52 by a cotranslational processing. The proteasome-mediated process ensures the production of both p52 and p100 and preserves their independent function. p52 binds to the kappa-B consensus sequence 5'-GGRNNYYCC-3', located in the enhancer region of genes involved in immune response and acute phase reactions. p52 and p100 are respectively the minor and major form; the processing of p100 being relatively poor. Isoform p49 is a subunit of the NF-kappa-B protein complex, which stimulates the HIV enhancer in synergy with p65.
Subunit : Component of the NF-kappa-B RelB-p52 complex. Homodimer; component of the NF-kappa-B p52-p52 complex. Component of the NF-kappa-B p65-p52 complex. Component of the NF-kappa-B p52-c-Rel complex. NFKB2/p52 interacts with NFKBIE. Component of a complex consisting of the NF-kappa-B p50-p50 homodimer and BCL3. Directly interacts with MEN1.
Subcellular Location : Nucleus. Cytoplasm. Note=Nuclear, but also found in the cytoplasm in an inactive form complexed to an inhibitor (I-kappa-B).
Post-translational modifications : While translation occurs, the particular unfolded structure after the GRR repeat promotes the generation of p52 making it an acceptable substrate for the proteasome. This process is known as cotranslational processing. The processed form is active and the unprocessed form acts as an i普魯士藍(lán)號(hào)：14038-43-8nhibitor (I kappa B-like), being able to form cytosolic complexes with NF-kappa B, trapping it in the cytoplasm. Complete folding of the region downstream of the GRR repeat precludes processing.
Subsequent to MAP3K14-dependent serine phosphorylation, p100 polyubiquitination occurs then triggering its proteasome-dependent processing.
Constitutive processing is tightly suppressed by its C-terminal processing inhibitory domain, named PID, which contains the death domain.
DISEASE : Note=A chromosomal aberration involving NFKB2 is found in a case of B-cell non Hodgkin lymphoma (B-NHL). Translocation t(10;14)(q24;q32) with IGHA1. The resulting oncogene is also called Lyt-10C alpha variant.
Note=A chromosomal aberration involving NFKB2 is found in a cutaneous T-cell leukemia (C-TCL) cell line. This rearrangement produces the p80HT gene which encodes for a truncated 80 kDa protein (p80HT).
Note=In B-cell leukemia (B-CLL) cell line, LB40 and EB308, can be found after heterogeneous chromosomal aberrations, such as internal deletions.
Similarity : Contains 7 ANK repeats.
Contains 1 death domain.
Contains 1 RHD (Rel-like) domain.
Database links : UniProtKB/Swiss-Prot: Q00653.4
英文名稱  Anti-Phospho-NFKB2(Ser866+Ser870)
中文名稱  磷酸化細(xì)胞核因子/k基因結(jié)合核因子p100抗體
別    名  NFKB2(phospho S869/S870); NFKB2(phospho Ser869/Ser870); p-NFKB2(S869/S870); p-NFKB2(Ser869/Ser870); DNA binding factor KBF2; H2TF1; Lymphocyte translocation chromosome 10; Lyt10; Oncogene Lyt 10; DNA binding factor d